Gamma Scintigraphy

Gamma scintigraphy is a versatile, non-invasive, imaging technique which offers early-stage evaluation of drug delivery systems in vivo, in real time.

Why use gamma scintigraphy?

Scintigraphy is a powerful, fast and incredibly effective clinical tool which can improve early drug development productivity by assessing critical product performance parameters which in vitro methods may not predict.

It provides direct quantification of formulation performance and can help evaluate pharmacodynamic effects on gastrointestinal (GI) transit, and when paired with pharmacokinetic data offers invaluable insight into the influence of drug delivery strategy on therapeutic outcomes. Scintigraphic data can also be used to support drug delivery claims, for marketing or regulatory purposes.

Applications in Drug Product Development

Assess prototype formulations
Lead candidate selection
In vitro / in vivo correlation
Dosage form erosion rates
Time and site of disintegration / dispersion

Applications in Physiological Effects

Gastric residence / emptying – solid and liquid phase
Gastrointestinal transit times
Mucociliary clearance
Deposition patterns
Food effects

BDD are market leaders in gamma scintigraphy with a proven track record and a global client base.

For more than 20 years, BDD have helped our clients with exciting and challenging studies to understand better how their products perform in man. We have performed studies across a wide range of dosage forms including tablets, capsules, respiratory products, drinks, eye drops and nasal administrations.

Our studies open up a range of in-vivo data that is critical to product performance that cannot be obtained in vitro or through simulation studies. Data such as site and rate of release, gastric emptying, residence time and even rate of swallowing alongside pharmacokinetic profiles can offer unparalleled insight into your product behaviour.

Our expert staff have years of experience in analysing and interpreting scintigraphic imaging data to work with you to understand fully the data obtained from these studies.

Gamma Scintigraphy can help you to:

Understand and visualise the performance of your dosage form in man
Rapidly screen formulations and provide data–backed decision making during early-stage formulation development
Evidence targeted drug release
Provide data for future regulatory submissions

Are you interested in understanding further how scintigraphy can help your product development?

Ask our Experts

World Class Drug Delivery Company

Clinical site

Glasgow Royal Infirmary
84 Castle St
Glasgow
G4 0SF, UK

+44 (0)141 552 8791

Formulation site

Bio-City Scotland
Bo’ness Road
Chapelhall, Newhouse
ML1 5UH, UK

+44 (0)141 404 9540

Website design by Genetic Digital